Health & Fitness
Health and Fitness
Health and Fitness
Tue, November 10, 2009
Mon, November 9, 2009 &;AElig;terna Zentaris: Scientific Article Supports Perifosine';s Development in Kidney Cancer
Article published in
The extensive article focuses on the role of the PI3K/Akt pathway in renal cell carcinoma pathogenesis, and on preclinical and clinical activity of compounds specifically targeting this pathway. Clinical data and perspectives on several compounds at different stages of development were also reviewed. The authors' conclusions on perifosine as a single agent or in combination therapy were based on data from several Phase 1 and Phase 2 studies in multiple types of cancer, including renal cell carcinoma.
The authors also mention the investigation of perifosine in sarcoma, pancreas, prostate and hepatocellular carcinomas, because of the pathogenetic relevance of the PI3K/Akt/mTOR signaling pathways in these cancers. They refer to the activity of perifosine in Waldenstrom's macroglobulinemia for which perifosine targets NFkappaB.
The article entitled, "Phosphatidylinositol-3-Kinase/Akt Signaling Pathway and Kidney Cancer, and the Therapeutic Potential of Phosphatidylinositol-3-Kinase/Akt Inhibitors", Camillo Porta and Robert A. Figlin, appears in the
About Perifosine
Perifosine is a novel oral anticancer agent that modulates several key signal transduction pathways, including Akt, MAPK, and JNK that have been shown to be critical for the survival of cancer cells. Perifosine has demonstrated both safety and clinical efficacy in several tumor types, both as a single agent and in combination with novel therapies. Perifosine is currently in Phase 2 clinical development for multiple tumor types, with a Phase 3 in multiple myeloma, under Special Protocol Assessment (SPA), pending commencement by year-end. Perifosine has also received Orphan Drug designation from the U.S. Food and Drug Administration (FDA) for the treatment of multiple myeloma.
About Æterna Zentaris Inc.
Æterna Zentaris Inc. is a global biopharmaceutical company focused on endocrine therapy and oncology, with proven expertise in drug discovery, development and commercialization. News releases and additional information are available at [ www.aezsinc.com ].
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