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??????????????,?52???,2???????????????????ONGLYZAa" (????)???????(HbA1c)??

_{//health-fitness.news-articles.net/content/2011/09/20/52-2--onglyzaa-hba1c.html}
^{Published in Health and Fitness on Tuesday, September 20th 2011 at 5:21 GMT by Market Wire}  

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ONGLYZAa''a"e'a"e"a"2aa...a'e..."eaia'aa'5a...aa'ia':

a a'a"aee"aie'"aa"aeaee"aeeaa'e"'a'eaae...;

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e"©a'3baaa'aaeaa®...a'a...aaaa'24a'""©iaa'a'28a'a'24a'a'e'"eea'(e"aa'e"aa"ae)aa'aONGLYZA 5a...'e...a'ea'(e"aa'e"aa"ae)aa'aa®...a''e..."HbA1caaaaaaa'e"©eaaa'e'iea'(e"aa'e"aa"ae)aa'aONGLYZA 5a..."HbA1caae™a...a'-0.75%ieea'(e"aa'e"aa"ae)aa'aa®...a'"e™a...a'-0.38% (pa < 0.0001)ia'"e®ae'a®a'a'aa'"a"®e"a52a'e'ONGLYZA"ea®a...a'a'a...iHbA1caaaaaea'aa'e(MTDDI)aeaeaa"HbA1c < 7%"'e...™a"a'a"ea'e'ae™aa"'e'iae®aae®a'a'e"a...e®a®e®ae'eiaaa'e(HbA1caaaa)"e'eeapost-hoc aa'

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52a'e'iea'(e"aa'e"aa"ae)aa'aONGLYZA 5a...'e...a'ea'(e"aa'e"aa"ae)aa'aa®...a'"""e"a'a':

• aaHbA1ci52a'e'iae...a'e'ae™a:
  -0.75% vs. -0.38% (p = < 0.0001i244aiea'aa'aONGLYZA 5a..."aa'8.67%i124aiea'aa'aa®...a'"aa'8.66%)a'
  • ae"aa'e"aa"ae'e..." HbA1ce™a...aa'
• ea'aa'eaaaa...a'+5.67aa/ vs. +6.67aa/a'
• ONGLYZA 5a..."a'21.3%"'e...eaeaa"HbA1c < 7%ia®...a'"a'8.7%"'e...eaeaa"HbA1c < 7%a'
• aaa"eaa...aaiONGLYZA 5a..."0.8aa... vs. a®...a'"0.5aa...(95% CI: a"0.3i0.9i246aiea'aa'aONGLYZA 5a..."aa'87.7aa...i125aiea'aa'aa®...a'"aa'86.2aa...)

a'e...a®52a'"©(ONGLYZA"a'a®...a'"a®aaa'81%a'83%)a'

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ea'aa'aONGLYZA 5a..."a'22.7%"'e...a'aeiea'aa'aa®...a'"a'a'26.5%i®e"aeaaa'7.6%a'6.6%a'®eaeaeia'"aeaaaa'eeaa 50a.../aaa'

ea'(e"aa'e"aa"ae)aa'aONGLYZA 5a..."a'ea'(e"aa'e"aa"ae)aa'aa®...a'""a...aa''ea'eaa(ONGLYZA 5a..."a'"a 5%)aaa'a':

• ae"" (7.9% vs. 7.9%)
• ea'' (6.3% vs. 6.6%)
• a'a'a'e""" (6.3% vs. 7.3%)
• a' (5.9% vs. 4.0%)
• ""®' (5.3% vs.3.3%)

ea'aa'aONGLYZA 5a..."a'25a'e...(8.2%)a'ea'a'a'ea'ea (SAE)iea'aa'aa®...a'"a'a'13a(8.6%)a'a'a'a"SAEs"'e...iea'aa'aONGLYZA 5a..."a'3aiea'aa'aa®...a'"a'a'ea'aa'aONGLYZA 5a..."a'i9a'e...(3.0%)aa'eaaea'"©ia...a'4aaa®a'a'ea'eaaa'ea'aa'aa®...a'"a'i3a'e...(2.0%)aa'eaaea'"©ia...a'a'ea'eaaa'ea'aa'aONGLYZA"a'2aaiaaa®aa'a...a'

a...a ONGLYZA^a" (™a)

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ONGLYZA^a" (™a)aa"eea®a...a

ea'"ae

• a'aaaeae"e©a": aea'ae©iaa'e"iaaeaea'aia'ONGLYZAe"a"eiaea'ae©"a'eeee™aiaaa'aeee™©a'
• ae®ea': ONGLYZAa...aaaa...e©aa'ae®ee™©""e®e®aa''a"©®a'

a''ea'eaa"

• ONGLYZA"a'a 5%aa'"a'"eaa...""a''ea'eaa"(e®"©e...aaa...e""aa'a) a'a'a'e"""(7.7%, 7.6%)aa'(7.5%, 5.2%)aea''(6.9%, 4.0%)a'ae""(6.8%, 6.1%)a'
• aa'a™a"'ae...®aa'"a"eiONGLYZA 2.5a..."a5a..."a'a®...a'"aa''e'a'"aaa'3.1%a8.1%a'4.3%a'

e©'a'a"

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®a"e

• e'aea®'e...: a'aeae'aea®eeee(e'e...'...e™[CrCl] a 50a/ae')"e'...'e...a'iONGLYZA (™a)a'ea'2.5a...ia'a'ONGLYZAa"aeea™ea'ONGLYZAaae...ee'e...a'ee"©a'ae®®ONGLYZAa"aaaaaa®e"ae'aea'
• aaa'a"aa: aaaa'eeea......a"aa...ea""©a'ONGLYZAa'a...aa...e©a'iaa®aa...eeaaae'a"a'™aaaaa'aaaa'"aaae©aaaa'aiONGLYZA"aa"aaa"a"a'
• a"''e...: ONGLYZAaa"''e...a'"a®a...a'a®a'

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