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Wed, September 30, 2009

Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline


Published on 2009-09-30 10:26:17, Last Modified on 2009-11-02 11:43:12 - Market Wire
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 - Combination with chemotherapy: A recent 40-patient randomized clinical trial (Journal of Immunotherapy, 2009, Volume 32, page 54- 65) established that front-line carboplatin-paclitaxel chemotherapy has immune adjuvant properties when administered concurrent to the anti-CA125 antibody, and immunity is enhanced relative to that which is achievable in an antibody treatment alone; - Combination with photodynamic therapy: In recent preclinical studies done at the BC Cancer Agency (Photochemistry and Photobiology, 2009, DOI:1111, European Patent No. 1,357,944), Quest showed that the therapeutic outcome of SL052 mediated photodynamic therapy can be improved by a combination with antibody mediated immunotherapy; and - Combination with radioimmuno therapy: The use of Oregovomab, radiolabeled with an appropriate therapeutic isotope, has the potential to provide the benefits of antibody mediated immune response as well as antigen-bearing tumor cell radiotoxicity. Such a concept has already been established in a preclinical setting (Applied Radiation and Isotopes, 1997, Volume 48, pages 899-906). 
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