SOUTH EASTON, MA--(Marketwire - May 16, 2012) - Pressure BioSciences, Inc. (OTCQB: [ PBIO ]) (PINKSHEETS: [ PBIO ]) ("PBI" or the "Company") today announced financial results for the 2012 first quarter and provided a business update.

Total revenue for the three months ended March 31, 2012 was $305,661 compared to $180,643 for the comparable period in 2011. Revenue from the sale of pressure cycling technology ("PCT") products and services was $164,772 for the first quarter of 2012 compared to $180,643 for the same period in 2011. Grant revenue in the first quarter of 2012 was $140,889; no grant revenue was reported during the same period in 2011. The Company installed seven PCT Sample Preparation Systems ("PCT Systems") during Q1 2012 compared to ten during the same period in 2011.

Operating loss for the first quarter of 2012 was $964,582, compared to $833,619 for the same period in 2011. This increase in operating loss was primarily due to higher investor relations, audit, tax, and legal costs related to the Company's financing activities. After the exclusion of non-cash charges, operating cash burn for the first quarter of 2012 was approximately $806,000 compared to approximately $724,000 for the first quarter of 2011. Loss per common share -- basic and diluted -- was $0.14 for the first quarter of 2012 compared to $0.34 for the same period in 2011.

Joseph L. Damasio, Vice President of Finance and Administration, said: "We made good progress during the quarter in our goal to adequately finance the Company. In February, we completed an $800,000 PIPE, half of which was debt converted into equity. In March, we set the wheels in motion to allow us to close a $500,000 registered direct offering on April 9^th. Over recent weeks, we have focused on achieving our goal to secure sufficient capital to properly finance PBI for rapid growth and future profitability."

Richard T. Schumacher, President and CEO of PBI, commented: "We reported a number of important achievements in the first quarter, including:

Total revenue increased 69%, from $180,643 to $305,661.
Measurable progress was made in the development of our automated, portable, high throughput PCT System and in a new PCT System to improve processing of cancer and other samples.
Strategic partnerships were announced with DigiLabs, Sage-N Research, and forensic expert Dr. Henry C. Lee. A distribution agreement with LA BioSystems (Benelux region) was announced.
Data were presented by nationally-recognized experts indicating that the PCT System offered significant advantages in sexual assault sample processing and in drug discovery applications."

Mr. Schumacher continued: "Our number one goal over the coming weeks is to secure sufficient financing to support our working capital needs both for the short term and for the next two years, including our expanded and more aggressive commercialization effort for our PCT product line. We are optimistic that we will successfully achieve this goal."

About Pressure BioSciences, Inc.

Pressure BioSciences, Inc. ("PBI") (OTCQB: [ PBIO ]) (PINKSHEETS: [ PBIO ]) is focused on the development, marketing, and sale of proprietary laboratory instrumentation and associated consumables based on Pressure Cycling Technology ("PCT"). PCT is a patented, enabling technology platform with multiple applications in the estimated $6 billion life sciences sample preparation market. PCT uses cycles of hydrostatic pressure between ambient and ultra-high levels to control bio-molecular interactions. PBI currently focuses its efforts on the development and sale of PCT-enhanced sample preparation systems (instruments and consumables) for mass spectrometry, biomarker discovery, bio-therapeutics characterization, vaccine development, soil and plant biology, forensics, histology, and counter-bioterror applications.

Forward Looking Statements

Statements contained in this press release regarding the Company's intentions, hopes, beliefs, expectations, or predictions of the future are "forward-looking'' statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward looking statements include the estimated size of the life sciences sample preparation market; the Company's plans and ability to secure sufficient financing to support working capital needs, including its expanded and more aggressive commercialization program; that data presented by nationally-recognized experts indicated that the PCT System offered significant advantages in sexual assault sample processing and in drug discovery applications; and that measurable progress was made in the development of the Company's automated, portable, high throughput PCT System and in a second PCT System intended to improve processing of cancer and other samples. These statements are based upon the Company's current expectations, forecasts, and assumptions that are subject to risks, uncertainties, and other factors that could cause actual outcomes and results to differ materially from those indicated by these forward-looking statements. These risks, uncertainties, and other factors include, but are not limited to: the Company's financial results for the quarter ended March 31, 2012 may not necessarily be indicative of future results as future revenues may not meet expectations due to the possible failure of the Company's products to achieve commercial acceptance, changes in customer's needs and technological innovations, expenses that may be higher than anticipated due to unforeseen costs or cost increases, and the Company may not secure sufficient capital to fully implement its plans; possible difficulties or delays in the implementation of the Company's strategies that may adversely affect the Company's continued commercialization of PCT; and the Company may not be successful in selling its PCT product line because scientists may not perceive the advantages of PCT over other sample preparation methods. Further, the Company will require additional working capital to fund its operations beyond the end of May 2012, and there can be no assurance that the Company will be successful in obtaining such financing on acceptable terms, if at all. Additional risks and uncertainties that could cause actual results to differ materially from those indicated by these forward-looking statements are discussed under the heading "Risk Factors" in the Company's Annual Report on Form 10-K for the year ended December 31, 2011, and other reports filed by the Company from time to time with the SEC. The Company undertakes no obligation to update any of the information included in this release, except as otherwise required by law.

PBI filed a registration statement (including a prospectus) with the SEC for an offering to which this communication may relate. Before you invest, you should read the prospectus in that registration statement for the offering and other documents PBI has filed with the SEC for more complete information about PBI and the offering. You may get these documents for free by visiting EDGAR on the SEC Web.

Visit us at our website [ http://www.pressurebiosciences.com ]

Consolidated Statements of Operations
(Unaudited)

			For the Three Months Ended
			March 31,
			2012			2011

Revenue:
	PCT products, services, other		$	164,772		$	180,643
	Grant revenue			140,889			-
		Total revenue		305,661			180,643

Costs and expenses:
	Cost of PCT products and services			78,194			78,929
	Research and development			271,611			218,965
	Selling and marketing			238,092			303,839
	General and administrative			682,346			412,529
		Total operating costs and expenses		1,270,243			1,014,262

		Operating loss		(964,582	)		(833,619	)

Other (expense) income:
	Interest (expense) income			(56,313	)		254
	Change in fair value of warrant derivative liability			(42,012	)		-
		Total other (expense) income		(98,325	)		254

	Net loss			(1,062,907	)		(833,365	)
	Accrued and deemed dividends on convertible preferred stock			(24,414	)		(133,090	)
	Net loss applicable to common shareholders		$	(1,087,321	)	$	(966,455	)


	Net loss per share attributable to common stockholders - basic and diluted		$	(0.14	)	$	(0.34	)

	Weighted average common stock shares outstanding used in the basic and diluted net loss per share calculation			7,712,539			2,836,971



Consolidated Balance Sheets

		March 31,			December 31,
ASSETS		2012			2011
		(Unaudited)			(Audited)
CURRENT ASSETS
Cash and cash equivalents		$	15,492		$	222,775
Accounts receivable, net of allowances of $9,600 at March 31, 2012 and December 31, 2011			203,998			269,237
Inventories			1,021,295			1,069,013
Prepaid income taxes			8,181			4,739
Prepaid expenses and other current assets			269,828			143,591
	Total current assets		1,518,794			1,709,355
PROPERTY AND EQUIPMENT, NET			72,006			89,171
OTHER ASSETS
Deposits			6,472			6,472
Intangible assets, net			121,604			133,762
TOTAL ASSETS		$	1,718,876		$	1,938,760

LIABILITIES AND STOCKHOLDERS' DEFICIT
CURRENT LIABILITIES
Accounts payable		$	1,129,515		$	890,676
Accrued employee compensation			224,766			180,437
Accrued professional fees and other			270,792			247,738
Deferred revenue			37,358			36,669
Promissory note			150,000			150,000
Convertible debt, net of unamortized discount of $0 at March 31, 2012 and $17,088 as of December 31, 2011			56,139			394,912
Warrant derivative liabilities			478,565			436,553
	Total current liabilities		2,347,135			2,336,985
LONG TERM LIABILITIES
Deferred revenue			7,579			10,111
TOTAL LIABILITIES			2,354,714			2,347,096
COMMITMENTS AND CONTINGENCIES
STOCKHOLDERS' DEFICIT
Series C convertible preferred stock, $.01 par value; 88,098 shares authorized; 88,098 shares issued and outstanding on March 31, 2012 and December 31, 2011 (Liquidation value of $1,101,225)			881			881
Series D convertible preferred stock, $.01 par value; 850 shares authorized; 300 shares issued and outstanding on March 31, 2012 and 743 shares issued and outstanding on December 31, 2011 (Liquidation value of $300,000)			3			7
Common stock, $.01 par value; 20,000,000 shares authorized; 8,499,898 shares issued and outstanding on March 31, 2012 and 6,723,993 shares issued and outstanding on December 31, 2011			84,999			67,240
Warrants to acquire preferred stock and common stock			2,510,504			2,203,101
Additional paid-in capital			14,358,536			13,823,875
Accumulated deficit			(17,590,761	)		(16,503,440	)
	Total stockholders' deficit		(635,838	)		(408,336	)
TOTAL LIABILITIES AND STOCKHOLDERS' DEFICIT		$	1,718,876		$	1,938,760

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Pressure BioSciences, Inc. Reports 69% Revenue Increase for Q1 2012

Pressure BioSciences, Inc. Reports 69% Revenue Increase for Q1 2012