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MONTREAL--([ BUSINESS WIRE ])--Sunshine Biopharma Inc. (OTCBB: SBFM) a development stage pharmaceutical company focused on the research, development and commercialization of drugs for the treatment of various forms of cancer, today announced that it has completed the pharmacokinetics studies in live rats for its lead anti-tumor compound, Adva-27a. Pharmacokinetics studies involve the determination of the fate of substances administered to a living organism. More specifically, pharmacokinetics refers to the study of the mechanisms of absorption and distribution of an administered drug, as well as the rate at which a drug action begins and the duration of the effect.

"It appears that Adva-27aas pharmacokinetics profile is significantly better than that of Etoposide. This, together with our previous observation that Adva-27a is able to overcome multidrug resistance in breast cancer cells further confirms the uniqueness of Adva-27a as an anti-cancer compound"

The pharmacokinetics studies Sunshine Biopharma recently completed analyzed the properties of Adva-27a and Etoposide in the plasma of live rats under a single intravenous bolus injection. While both Adva-27a and Etoposide had a mean terminal phase plasma half-life of approximately one hour, Adva-27a produced a 2.8-fold higher plasma initial concentration (C= 8779 ng/mL) than Etoposide (C= 3183 ng/mL). In addition, the area under the plasma concentration-versus-time curve for Adva-27a (AUC_inf = 2211 hr-ng/mL) was 2.4-times higher than that of Etoposide (AUC_inf = 933 hr-ng/mL). Moreover, Adva-27a had significantly lower plasma clearance rate (CL = 19.0 mL/min/kg) compared to Etoposide (CL = 44.7 mL/min/kg).

aThese are very interesting resultsa, said Dr. Steve N. Slilaty, Sunshineas President and CEO. aIt appears that Adva-27aas pharmacokinetics profile is significantly better than that of Etoposide. This, together with our previous observation that Adva-27a is able to overcome multidrug resistance in breast cancer cells further confirms the uniqueness of Adva-27a as an anti-cancer compound,a he added.

Sunshine Biopharma is currently conducting the next sequence of steps in its development of Adva-27a which include GMP manufacturing, IND-enabling studies, filing of an IND application followed by Phase I clinical trials in humans.

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